Corsi F, Fiandra L, Rizzardini G. New perspectives on nanotechnology and antiretroviral drugs: a 'small' solution for a big promise in HIV treatment?. AIDS. 2016;30(6):963-964. doi:10.1097/QAD.0000000000001026. PMID: 26807964.
In this issue, Li et al. present a well designed multidisciplinary study, aimed to demonstrate the potential benefit of a multifunctional polymeric nanodevice for delivering HIV treatment. The study offers a new perspective on the use of nanotechnology for combination HIV management, as the proposed system is a smart biodegradable poly lactic acid-based nanoparticle with a double therapeutic function that encapsulates the nonnucleoside reverse transcriptase inhibitor (NNRTI) 14f with the surface conjugated to the third-generation HIV-1 fusion inhibitor T1144.